Buckhunter i have dug ginseng right in amongst mayapples so i don't know if it would hurt or not. My guess probably not, the only problem that i can think of is where it would be young ginseng competing with the mayapple the mayapple may win where they are so thick. Maybe you should try a small plot in amongst the mayapples and see how it goes before getting rid of them and investing a bunch of money in seeds. Or you could go with older rootlets they don't have as harder time competing and have a higher success rate on living, but they are also more expensive. But you really need to get someone on here who has more experience in growing than i do to give you a more in depth answer hope i helped you some.